In many past studies, adiponectin plays some roles in inflammation, angiogenesis and tissue remodelling, and induces the production of the anti-inflammatory mediators. The lack of correlation between psoriasin and lung involvement could be explained considering that only the monomeric form is linked to reduced DL CO , pulmonary fibrosis and ground-grass opacity, as previously observed, and that ELISA assay can't discriminate between the three forms. To perform a large and independent replication study of the TNSF4 variants in SSc and to perform a meta-analysis of available data in order to clarify the level of association and subsets with preferential associations. We have previously shown that a transgenic mouse model develops many features of SSc including susceptibility to vasculopathy and lung fibrosis. In T-cell lines generated from the skin
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